วันพุธที่ 21 มกราคม พ.ศ. 2558

Assignment1_Citation

Abstract
Curcumin, a natural yellow colourant from turmeric, is insoluble in water. It has been rendered water-soluble by preparation of suitable amino acid derivatives. Several amino acid conjugates of curcumin were synthesised in high yields (45–76%). These curcumin derivatives were soluble in water at 1–10 mg/ml concentrations. Derivatives of curcumin with alkyl-substituted amino acids, such as alanine, valine, serine and cysteine, exhibited smaller IC50 values (˜50%) than did curcumin in antioxidant assays. With respect to anti-mutagenicity against Salmonella typhimurium TA 98 and TA 1531, the derivatives showed an effect stronger than or, in a few cases, similar to curcumin. These results clearly demonstrated that the conjugation of curcumin at the phenolic position with amino acids, while rendering the molecule water-soluble, led to the improvement of several of its in vitro biological attributes, the effect being more pronounced in the case of specific alkyl-substituted amino acids.

APA style reference
      Curcumin-amino acid was synthesized by conjugation of curcumin with 
      amino acids improved solubility in the water and increased antioxidant and 
      antimutagenic activities of curcumin (Parvaty et al., 2011).

   1. Parvaty et al. (2011) found that curcumin-amino acid was synthesized 
      by conjugation of curcumin with amino acids improve solubility in the water 
      and increased antioxidant and antimutagenic activities of curcumin.

   2. The solubility in water, antioxidant and antimutagenic activities of curcumin were 
       enhanced by conjugation of curcumin with amino acids (Parvaty et al., 2011).

Reference
 Parvathy K. S., Negi P. S. and Srinivas P. Curcumin–amino acid conjugates: Synthesis, antioxidant and  antimutagenic attributes. Food Chemistry. 2010. 120: 523-530.     
     


8 ความคิดเห็น:

  1. Hi Chawanphat

    I will change your citation in No.1 because i have seen many verb in your sentences.

    "Parvalty et al. (2011) found that the conjugation of curcumin with amino acids was synthesized for improved water-solubility and increased some activities of curcumin (p. 523)."

    In my opinion, you should be careful for parallel of sentences. "improve ... and increased..." --> it isn;t parallel.

    Fighting !!!

    ตอบลบ
  2. Good start! Your friend made a good suggestion. Also, check your reference list entry; that is not correct APA citation style.

    ตอบลบ
  3. ความคิดเห็นนี้ถูกผู้เขียนลบ

    ตอบลบ
  4. Hello Chawaphat

    I would like to revise a bit on your citation No.1 to make the sentense better.

    1. Parvaty et al. (2011) found that curcumin-amino acid which was synthesized by conjugation of curcumin with amino acids improved solubility in the water, increased antioxidant and antimutagenic activities of curcumin.

    or you can make the sentence simpler by replacing the cluase " curcumin-amino acid which was synthesized by conjugation of curcumin with amino acids " to "amono acid conjugated-curcumin"

    If you think different, you can reply me.

    Cheers.

    ตอบลบ
  5. Hello! K.Chawanphat
    There are many suggests about your citation above^^ and I 'd like to suggest more about this because you had the information at the reference. So, you should add it in your citation such as The solubility in water, antioxidant and antimutagenic activities of curcumin were enhanced by conjugation of curcumin with amino acids (Parvaty et al., 2011, p.523). ^^

    ตอบลบ
  6. Hi Chawanphat,

    I have one suggestion^^. You should change a few thing in your citation 1 as Parvaty et al. (2011) found that curcumin-amino acid was synthesized by conjugation of curcumin with amino acids to improve solubility in the water and increase antioxidant and antimutagenic activities of curcumin.

    ตอบลบ
  7. Hello K. Chawanphat,
    I don't understand about the antioxidant in curcumin, how do you protect and keep quality of curcumin? because i bought curcumin (supplement) from shop, some brand it's very expensive.I believe that curcumin is the best supplement.

    ตอบลบ